Long-term potentiation

Long-term potentiation (LTP) is thought to be the molecular event that contributes to learning. In a nutshell, LTP helps move whatever it is you’re learning from short-term memory to long-term memory. If you’re really bored you can watch a video that explains it better here.

There’s a lot of interesting research out there regarding chemically induced LTPs. I won’t bore you with the science behind it but should you want to learn more you can read the original research here.

The original experimenter attempting to create a  CILTEP (Chemically Induced Long TErm Potentiation) was Abelard Lindsay. Here’s a link to an interesting interview of Abelard.

The idea behind creating CILTEP involves inhibiting PDE4 while promoting the production of cAMP. This can be done, as the name would suggest, with some chemicals. Namely artichoke extract, as a PDE4 inhibitor, and Forskolin to increase cAMP levels.

If you want to absorb more of the information that you come into contact with then perhaps CILTEP is for you. It’s not going to give you the powers that Eddie Morra gained from taking NZT-48, but it might help in retention.

I took the following stack religiously, first thing in the morning on an empty stomach, for 5 weeks:

  • 800 mg of artichoke extract
  • 500 mg of L-Phenylalanine (don’t mistake this for DL-Phenylalanine)
  • 20 mg of Coleus Forskohlii root extract to get 4 mg of forskolin (check the label to see %)
  • 10 mg of vitamin B6

I’d wash this stack down with 10 oz of water mixed with a scoop of green super food for the micro-nutrients. Sadly, I’d say that I didn’t notice anything as far as retention goes or even an increased desire to learn for that matter. Bottom line is that the science behind it is cool and I so wanted it to work. I’m not giving up because I know you can get some bunk supplements and the levels might not be exact. I could also be a non-responder. I’ll continue to try different levels, other supplements, etc. all while measuring for changes.

I mention measuring for changes as that is an important part of understanding whether or not a nootropic is having an impact on you. It is extremely easy to fall victim to the placebo effect with this or any other nootropic stack. In my next post I’ll share the resources I used to keep track of my brain changes (or lack thereof).